Opsoclonus and polymyoclonia complicating oat-cell carcinoma of the bronchus.
نویسندگان
چکیده
Opsoclonus, originally described by Orzechowski (1927), may be defined as continuous irregular, chaotic, conjugate eye movement in all directions (Smith and Walsh, 1960). Often, although not invariably, it occurs in conjunction with myoclonic movements affecting the head and limbs. The syndrome has been reported most frequently among infants and children (Smith and Walsh, 1960; Cogan, 1954; Marmion and Sandilands, 1947; Kinsbourne, 1962; Baringer, Sweeney and Winkler 1968; Dyken and Kolar, 1968; Kennedy and Tucker, 1962; Bolthauser, Deonna and Hirt, 1979) although these accounts and others do include a few adult cases (Bolthauser et al., 1979; McLean, 1970). The aetiology often remains uncertain although a viral infection has frequently been suggested when there has been a prodromal upper respiratory tract infection or minor febrile illness. Sometimes the cerebro-spinal fluid (CSF) has contained excessive lymphocytes. Serological evidence of infection has only been given in isolated cases; mumps virus (Baringer et al., 1968), St Louis encephalitis virus (Estrim, 1977) and psittacosis (Blue, Janeway and Stanley, 1971). Solomon and Chutorian (1968) were the first to describe opsoclonus in association with an occult neuroblastoma of childhood and since then there have been many similar reports (Bolthauser et al., 1979) confirming this relationship. Although isolated cases have been reported in association with such diverse condition as vertebro-basilar ischaemia (Bri-
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عنوان ژورنال:
- Postgraduate medical journal
دوره 58 685 شماره
صفحات -
تاریخ انتشار 1982